H.U.M.A.N.W.I.N.E. (often stylized HUMANWINE) is an American Vermont-based band with early roots in Boston, Massachusetts, United States. Founded in 2002 by Holly Brewer and Matthew McNiss, HUMANWINE has had a long history of rotating lineups of supporting musicians. In recent years, the band has primarily performed and recorded as a duo, as heard on their 2016 four-volume release "aether".

HUMANWINE has received various nominations and awards. The band has been featured in articles in many sources including the Boston Phoenix, the Boston Herald, The Pitch, The Dallas Morning News, and the Worcester Telegram & Gazette, as well as being featured on the cover of Northeast Performer Magazine.

HUMANWINE has opened for acts at both the Orpheum Theatre in Boston and Webster Hall in New York. They have also opened for the Squirrel Nut Zippers at the Paradise Rock Club in Boston as well as headlining their own show at the venue.

Their name is said, with tongue in cheek, to be an acronym of the phrase, "Humans Underground Making Anagrams Nightly While Imperialistic Not-Mes Enslave", a reference to the subtly-coded lyrics that comprise most of their songs.