Jean Derome (born June 29, 1955) is a French Canadian avant-garde saxophonist, flautist, and composer. A prominent figure in the Montreal musique actuelle (new music) scene, Derome has been a member of experimental, jazz, and rock groups, and has appeared on over 30 albums, including seven solo albums. He has written scores for over 30 films and co-founded Ambiances Magnétiques, a Canadian musical collective and independent record label.
In 1992, Derome won the second annual Canadian Freddie Stone Award.