Most Precious Blood is an American hardcore punk band from New York City, United States, formed from the remnants of the band Indecision. They blend the song structures of hardcore with heavy metal, and the band cites Sick of it All, Aphex Twin, The Sisters Of Mercy, and The Obsessed as influences, among others. They were signed to Trustkill Records until it dissolved in 2010. They are now with Trustkill president Josh Grabelle's new label Bullet Tooth.
The band and its members advocated straight edge, vegetarianism and veganism, and they were all animal rights belligerents. As of 2015, vocalist Rob Fusco is no longer. However, they deny being preachy in any way, saying "I'm not going around trying to change people because people are going to change when they want to... if I said something that you found truth in, or that you found made sense, cool - I'm glad I was a catalyst to help you come to your own conclusions."