Sixer or Sixers may refer to:

  • Sixer (2007 film), an Indian Kannada-language film
  • Sixer (2019 film), an Indian Tamil-language film
  • Philadelphia 76ers, a professional basketball team in Philadelphia, Pennsylvania, United States
  • Fort Worth Sixers, a National Indoor Football League franchise in the United States
  • Cricket:
    • Sydney Sixers, an Australian cricket franchise
    • Sixer (cricket), an act of scoring six runs
  • Southern Sixers, mountains in the southern United States which are at least six thousand feet tall
  • Stephen Kellogg and the Sixers, an American rock band
  • The members of the sixth pilgrimage to Terra Nova, the settlement in the U.S. TV series of the same name
  • Sixer, one of the senior youth members of a Pack, who leads a team called a "Six"
  • Sixers, the slang term for members of the IOI in Ready Player One